摘要
<jats:p>Ovine interferon tau (IFN-τ) is a unique type I interferon with low toxicity and a broad host range<jats:italic>in vivo</jats:italic>. We report the generation of a nonreplicative recombinant adenovirus expressing biologically active IFN-τ. Using the B6.A2G-Mx1 mouse model, we showed that single-dose intranasal administration of recombinant Ad5-IFN-τ can effectively prevent lethality and disease induced by highly virulent hv-PR8 influenza virus by activating the interferon response and preventing viral replication.</jats:p>
- 出版日期2016-4