Osborn waves following out-of-hospital cardiac arrest-Effect of level of temperature management and risk of arrhythmia and death

作者：Hadziselimovic Edina; Thomsen Jakob Hartvig; Kjaergaard Jesper; Kober Lars; Graff Claus; Pehrson Steen; Nielsen Niklas; Erlinge David; Frydland Martin; Wiberg Sebastian; Hassager Christian

来源：Resuscitation, 2018, 128: 119-125.

DOI：10.1016/j.resuscitation.2018.04.037

• Cardiac arrest
• Hypothermia
• Repolarization
• Ventricular arrhythmia
• Cardiac arrhythmia
• Osborn waves
• J-waves
• Out-of-hospital cardiac arrest
• Targeted temperature management
• Therapeutic hypothermia
• TTM

Background: The Osborn or J-wave, an upright deflection of the J-point on the electrocardiogram (ECG), is often observed during severe hypothermia. A possible relation between Osborn waves (OW) and increased risk of ventricular arrhythmia has been reported. We sought to determine whether the level of targeted temperature management (TTM) following out-of-hospital cardiac arrest (OHCA) affects the prevalence of OW and to assess the associations between OW and risk of ventricular arrhythmia and death.
Methods and results: The present study is part of the TTM-trial ECG-substudy (including OHCA-patients randomized to TTM at 33 degrees C vs. 36 degrees C from 24 of 36 sites). Serial 12-lead ECGs from 680 (94%) patients were analysed and stratified by OW at predefined time-points (0, 4, 28, 36, 72-h after admission).
On admission, the overall prevalence of OW was 16%, increasing to 32% at target temperature, with higher prevalence in the 33 degrees C-group (40% vs. 23%, p < 0.0001). No difference in prevalence was found between the 33 degrees C- and 36 degrees C-groups on admission (18% vs. 14%, p = .11) or after rewarming (13% vs. 10%, p = .44). OW were not associated with increased risk of ventricular arrhythmia (Odds ratio = 0.78 (0.51-1.20), p = .26), but associated with significantly lower 180-day mortality as compared to no OW (38% vs. 52%, p(log-rank) = 0.001) in univariable analyses only.
Conclusion: OW are frequent during TTM, particularly in patients treated with 33 degrees C. OW are not associated with increased risk of ventricular arrhythmia, and may be considered a benign physiological phenomenon, associated with lower mortality in univariable analyses.

• 出版日期2018-7