A PHASE II COMPARATIVE STUDY OF GROSS TUMOR VOLUME DEFINITION WITH OR WITHOUT PET/CT FUSION IN DOSIMETRIC PLANNING FOR NON-SMALL-CELL LUNG CANCER (NSCLC): PRIMARY ANALYSIS OF RADIATION THERAPY ONCOLOGY GROUP (RTOG) 0515

作者：Bradley Jeffrey^*; Bae Kyounghwa; Choi Noah; Forster Ken; Siegel Barry A; Brunetti Jacqueline; Purdy James; Faria Sergio; Vu Toni; Thorstad Wade; Choy Hak

来源：International Journal of Radiation Oncology, Biology, Physics, 2012, 82(1): 435-441.

DOI：10.1016/j.ijrobp.2010.09.033

• Lung cancer
• FDG-PET
• Mediastinal nodal staging
• mediastinum

Background: Radiation Therapy Oncology Group (RTOG) 0515 is a Phase II prospective trial designed to quantify the impact of positron emission tomography (PET)/computed tomography (CT) compared with CT alone on radiation treatment plans (RTPs) and to determine the rate of elective nodal failure for PET/CT-derived volumes. %26lt;br%26gt;Methods: Each enrolled patient underwent definitive radiation therapy for non small-cell lung cancer (%26gt;= 60 Gy) and had two RTP datasets generated: gross tumor volume (GTV) derived with CTalone and with PET/CT. Patients received treatment using the PET/CT-derived plan. The primary end point, the impact of PET/CT fusion on treatment plans was measured by differences of the following variables for each patient: GTV, number of involved nodes, nodal station, mean lung dose (MLD), volume of lung exceeding 20 Gy (V20), and mean esophageal dose (MED). Regional failure rate was a secondary end point. The nonparametric Wilcoxon matched-pairs signed-ranks test was used with Bonferroni adjustment for an overall significance level of 0.05. %26lt;br%26gt;Results: RTOG 0515 accrued 52 patients, 47 of whom are evaluable. The follow-up time for all patients is 12.9 months (2.7-22.2). Tumor staging was as follows: 11 = 6%; IIIA = 40%; and IIIB = 54%. The GTV was statistically significantly smaller for PET/CT-derived volumes (98.7 vs. 86.2 mL; p %26lt; 0.0001). MLDs for PET/CT plans were slightly lower (19 vs. 17.8 Gy; p = 0.06). There was no significant difference in the number of involved nodes (2.1 vs. 2.4), V20 (32% vs. 30.8%), or MED (28.7 vs. 27.1 Gy). Nodal contours were altered by PET/CT for 51% of patients. One patient (2%) has developed an elective nodal failure. %26lt;br%26gt;Conclusions: PET/CT-derived tumor volumes were smaller than those derived by CT alone. PET/CT changed nodal GTV contours in 51% of patients. The elective nodal failure rate for GTVs derived by PET/CT is quite low, supporting the RTOG standard of limiting the target volume to the primary tumor and involved nodes.

• 出版日期2012-1