Clinical significance of serum ferritin level as an independent predictor of insulin resistance in Korean men

作者：Park Sung Keun; Choi Won Joon; Oh Chang Mo; Kim Min Gi; Ham Woo Taek; Choi Joong Myung; Ryoo Jae Hong^*

来源：Diabetes Research and Clinical Practice, 2015, 107(1): 187-193.

DOI：10.1016/j.diabres.2014.08.022

• Ferritin Insulin resistance
• HOMA-IR

Aims: Elevated serum ferritin level has been reported to be associated with type 2 diabetes mellitus and metabolic syndrome, which have significant relation with insulin resistance (IR). However, clinical association between serum ferritin level and IR remained unclear. Accordingly, this study was designed to evaluate the longitudinal effects of baseline serum ferritin level on the development of IR.
Methods: An IR-free 22,057 healthy Korean men (HOMA-IR < 2.7), who had participated in a medical health check-up program in 2005, were followed up until 2010. During follow up, the development rate of IR, defined in case of HOMA-IR >= 2.7, was monitored according to the quartile groups of serum ferritin levels. Cox proportional hazards models were used to measure the hazard ratios (HRs) of baseline serum ferritin levels on IR.
Results: During 77,471.1 person-years of follow-up, 4494 incident cases of insulin resistance developed between 2006 and 2010 (overall development rate: 20.4%). The development rate of IR increased in proportion to the baseline serum ferritin levels (quartile 1: 16.7%, quartile 2: 18.5%, quartile 3: 19.9%, quartile 4: 25.5%, P < 0.001). After adjusting for multiple covariates, the HRs (95% CI) for IR, comparing the second to the fourth quartile of serum ferritin levels with the first quartile, were 1.11 (0.99-1.24), 1.19 (1.07-1.33) and 1.51 (1.35-1.68), respectively (P for trend < 0.001).
Conclusions: Elevated serum ferritin level was independently associated with the future development of IR in Korean men.

• 出版日期2015-1