Alpha-phellandrene Promotes Immune Responses in Normal Mice Through Enhancing Macrophage Phagocytosis and Natural Killer Cell Activities

作者：Lin Jen Jyh; Lin Ju Hwa; Hsu Shu Chun; Weng Shu Wen; Huang Yi Ping; Tang Nou Ying; Lin Jaung Geng; Chung Jing Gung^*

来源：In Vivo, 2013, 27(6): 809-814.

• alpha-Phellandrene
• BALB/c mice
• phagocytosis
• macrophage
• natural killer cells

alpha-Phellandrene, a natural compound from natural plants, has been used in the food and perfume industry. We investigated the effects of alpha-phellandrene on the immune responses on normal murine cells in vivo. Normal BALB/c mice were treated orally with or without alpha-phellandrene at 0, 1, 5 and 25 mg/kg and olive oil as a positive control for two weeks. Results indicated that alpha-phellandrene did not change the weight of animals when compared to olive oil (vehicle for alpha-phellandrene)-treated groups. After flow cytometric assay of blood samples it was shown that alpha-phellandrene increased the percentage of CD3 (T-cell marker), CD11b (monocytes) and MAC3 (macrophages), but reduced the percentage of CD19 (B-cell marker) cell surface markers in alpha-phellandrene-treated groups, compared to untreated groups. alpha-Phellandrene promoted the phagocytosis of macrophages from blood samples at 5 and 25 mg/kg treatment and promoted natural killer cell activity from splenocytes at 25 mg/kg. Furthermore, alpha-phellandrene increased B- cell proliferation at 25 mg/kg with or without stimulation but promoted cell proliferation only at 25 mg/kg treatment with stimulation. Based on these observations, 25 mg/kg with alpha-phellandrene seems to have promoted immune responses in this murine model.

• 出版日期2013-12
• 单位中国医科大学