Use of Low-dose Ketamine Infusion for Pediatric Patients With Sickle Cell Disease-related Pain A Case Series

作者：Zempsky William T^*; Loiselle Kristin A; Corsi John M; Hagstrom J Nathan

来源：The Clinical Journal of Pain, 2010, 26(2): 163-167.

• sickle cell disease
• ketamine
• vasoocclusive pain

Objectives: Sickle cell disease-related pain is difficult to treat adequately. Pain secondary to vasoocclusive episodes (VOE) may be unresponsive to high-dose intravenous opiates. Alternative treatment options for VOE are needed. We sought to review our experience with low-dose ketamine for children hospitalized with VOE.
Methods: Retrospective medical chart reviews were conducted for hospitalized patients treated with ketamine for sickle cell VOE. Data gathered included vital signs, pain scores, opiate utilization, and adverse events.
Results: Five children and adolescents received a low-dose ketamine infusion for the treatment of sickle cell-related pain. Four received the infusion in addition to opiates (delivered via patient controlled analgesia) as a rescue intervention after several days of inadequate pain relief and I patient received ketamine in place of opiates. Two of the 5 patients achieved what seems to be clinically significant pain control with a low-dose ketamine infusion, whereas I additional patient had significant reduction in opiate utilization.
Discussion: Further research into ketamine for vasoocclusive pain is warranted.

• 出版日期2010-2