Marked Elevation of Hepatic Transaminases in Recipients of an Orthotopic Liver Transplant from a Brain-Dead Donor Receiving Extracorporeal Membrane Oxygenation

作者：Chen Teng Wei; Hsieh Chung Bao; Chan De Chuan; Yu Jyh Cherng; Kuo Shih Ming; Tsai Chien Sung; Fan Hsiu Lung^*

来源：Annals of Transplantation, 2014, 19: 680-687.

DOI：10.12659/aot.891335

• Brain Death
• Extracorporeal Membrane Oxygenation
• Liver Transplantation

Background: Hemodynamic instability can lead to failure of donor organ procurement in brain-dead donors. Extracorporeal membrane oxygenation (ECMO) has been used in non-heart-beating donors to increase the donor pool, but the use of ECMO to salvage donor organs has been rarely used. We aimed to analyze postoperative liver function test results in patients receiving orthotopic liver transplants from ECMO-supported brain-dead donors.
Material/Methods: We retrospectively reviewed the records of 43 recipients of orthotopic liver transplantation from May 2009 to June 2012. Six recipients received liver grafts from ECMO-maintained donors designated as the ECMO group (n=6). The remaining patients were assigned to the non-ECMO group (n=37). Complication and mortality rates and liver function test results on postoperative days 1, 3, 5, 7, and 14 were compared between the 2 groups.
Results: Serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase levels were significantly elevated on postoperative Day 1 in the ECMO group. There were no significant differences in the complication and overall survival rates between the 2 groups (P=0.411).
Conclusions: Although serum transaminases markedly elevated on postoperative Day 1, ECMO successfully preserved potential liver grafts in hemodynamically unstable brain-dead donors.

• 出版日期2014-12-29