Utility of Cystatin C for Estimating Glomerular Filtration Rate in Patients With Muscular Dystrophy A Good Agreement With Inulin Clearance

作者：Kimura Koichi^*; Morita Hiroyuki; Daimon Masao; Horio Masaru; Kawata Takayuki; Nakao Tomoko; Hirokawa Megumi; Kitao Ruriko; Watanabe Daisuke; Komori Tetsuo; Nagata Tetsuya; Takeda Shin'ichi; Komaki Hirofumi; Segawa Kazuhiko; Nakajima Takashi; Takenaka Katsu; Komuro Issei

来源：International Heart Journal, 2016, 57(3): 386-388.

• Heart failure
• Sudden death
• Renal function
• Creatinine
• Inulin

Emerging concerns regarding heart failure, arrhythmia, and sudden death in patients with muscular dystrophy are of significant clinical importance. On the other hand, little attention has been paid to renal dysfunction because these patients have low serum creatinine levels. Serum cystatin C, unaffected by muscle quantity, is a potentially superior marker for estimating renal function. Here, we present cases with muscular dystrophy in which estimated glomerular filtration rate (GFR) by cystatin C (eGFRcys) provided good agreement with simultaneously measured GFR by inulin renal clearance (differences less than 20%). Sudden death with acute heart failure occurred in a patient with underlying renal dysfunction and elevated BNP. Neurologists and cardiologists should evaluate renal function using GFR with cystatin C in patients with muscular dystrophy.

• 出版日期2016-5