A Stable Isotope Biomarker of Marine Food Intake Captures Associations between n-3 Fatty Acid Intake and Chronic Disease Risk in a Yup%26apos;ik Study Population, and Detects New Associations with Blood Pressure and Adiponectin

作者：O' Brien Diane M; Kristal Alan R; Nash Sarah H; Hopkins Scarlett E; Luick Bret R; Stanhope Kimber L; Havel Peter J; Boyer Bert B

来源：Journal of Nutrition, 2014, 144(5): 706-713.

DOI：10.3945/jn.113.189381

The nitrogen isotope ratio (delta N-15) of RBCs has been proposed as a biomarker of marine food intake in Yup%26apos;ik people based on strong associations with RBC eicosapentaenoic acid (EPA) and docosahexaenoic acid (DNA). However, EPA and DHA derive from marine fats, whereas elevated delta N-15 derives from marine protein, and these dietary components may have different biologic effects. Whether delta N-15 is similarly associated with chronic disease risk factors compared with RBC EPA and DHA is not known. We used covariate-adjusted linear models to describe biomarker associations with chronic disease risk factors in Yup%26apos;ik people, first in a smaller (n = 363) cross-sectional study population using RBC EPA, DHA, and delta N-15, and then in a larger (n = 772) cross-sectional study population using delta N-15 only In the smaller sample, associations of BBC EPA, DHA, and delta N-15 with obesity and chronic disease risk factors were similar in direction and significance: delta N-15 was positively associated with total, HDL, and LDL cholesterol, apolipoprotein A-I, and insulin-like growth factor binding protein-3 (IGFBP-3), and inversely associated with triglycerides Based on comparisons between covariate-adjusted beta-coefficients, EPA was more strongly associated with circulating lipids and lipoproteins, whereas delta N-15 was more strongly associated with adipokines, the inflammatory marker interleukin-6, and IGFBP-3. In the larger sample there were new findings for this population: delta N-15 was inversely associated with blood pressure and there was a significant association (with inverse linear and positive quadratic terms) with adiponectin. In conclusion, delta N-15 is a valid measure for evaluating associations between EPA and DHA intake and chronic disease risk in Yup%26apos;ik people and may be used in larger studies. By measuring delta N-15, we report beneficial associations of marine food intake with blood pressure and adiponectin, which may contribute to a lower incidence of some chronic diseases in Yup%26apos;ik people.

• 出版日期2014-5