Absence of association between atherosclerotic cerebral infarction and TNFSF4/TNFRSF4 single nucleotide polymorphisms rs1234313, rs1234314 and rs17568 in a Chinese population

作者：Huang, Qing; Yang, Qi-Dong; Tan, Xing-Lin; Feng, Jie; Tang, Tao; Xia, Jian; Zhang, Le; Huang, Li; Bai, Yong-Ping; Liu, Yun-Hai^*

来源：Journal of International Medical Research, 2014, 42(2): 436-443.

DOI：10.1177/0300060514521154

• Atherosclerosis
• cerebral infarction
• SNP
• TNFSF4
• TNFRSF4

Objective To clarify the association between atherosclerotic cerebral infarction (ACI) and the single nucleotide polymorphisms (SNP) rs1234313 and rs1234314 (in TNFSF4) and rs17568 (in TNFRSF4).
Methods Genomic DNA was extracted from peripheral blood of patients with ACI and healthy control subjects. The presence of carotid plaque was determined. Rs1234313, rs1234314 and rs17568 were characterized via SNP genotyping assay and verified by DNA sequencing.
Results Genotype distributions were in Hardy-Weinberg equilibrium. There were no significant differences in the allele and genotype distributions of rs1234313, rs1234314 and rs17568 between patients with ACI (n=450) and healthy control subjects (n=378), or between patients with ACI and carotid plaque (n=342) and controls.
Conclusions There were no significant associations between rs1234313, rs1234314 and rs17568 and ACI risk in a Han Chinese population.

• 出版日期2014-4
• 单位中南大学