Non-invasive identification of melanoma with near-infrared and skin impedance spectroscopy

作者：Boden Ida; Nystrom Josefina; Lundskog Bertil; Zazo Virginia; Geladi Paul; Lindholm Sethson Britta^*; Naredi Peter

来源：Skin Research and Technology, 2013, 19(1): E473-E478.

DOI：10.1111/j.1600-0846.2012.00668.x

• NIR
• PLS-DA classification
• combination probe
• skin cancer
• in vivo

Background/purpose: An early diagnosis of cutaneous malignant melanoma is of high importance for good prognosis. An objective, non-invasive instrument could improve the diagnostic accuracy of melanoma and decrease unnecessary biopsies. The aim of this study was to investigate the use of Near-infrared and skin impedance spectroscopy in combination as a tool to distinguish between malignant and benign skin tumours.
Methods: Near-infrared and skin impedance spectra were collected in vivo on 50 naevi or suspect melanomas prior to excision. Received data were analysed using multivariate techniques and the results were compared to histopathology analyses of the tumours. A total of 12 cutaneous malignant melanomas, 19 dysplastic naevi and 19 benign naevi were included in the study.
Results: The observed sensitivity and specificity of the proposed method were 83% and 95%, respectively, for malignant melanoma.
Conclusion: The results indicate that the combination of near-infrared and skin impedance spectroscopy is a promising tool for non-invasive diagnosis of suspect cutaneous malignant melanomas.

• 出版日期2013-2