Neurobiology of the Premonitory Urge in Tourette's Syndrome: Pathophysiology and Treatment Implications

作者：Cavanna Andrea E^*; Black Kevin J; Hallett Mark; Voon Valerie

来源：Journal of Neuropsychiatry and Clinical Neurosciences, 2017, 29(2): 95-104.

DOI：10.1176/appi.neuropsych.16070141

Motor and vocal tics are relatively common motor manifestations identified as the core features of Tourette's syndrome (TS). Although traditional descriptions have focused on objective phenomenological observations, such as anatomical location, number and frequency of tics, patients' first-person accounts have consistently reported characteristic subjective correlates. These sensory phenomena are often described as a feeling of mounting inner tension or urge to move ("premonitory urge"), which is transiently relieved by tic expression. This article reviews the existing literature on the clinical and neurobiological aspects of the premonitory urge in patients with TS, with focus on its pathophysiology and possible treatment implications.

• 出版日期2017
• 单位NIH