Antidiabetic Effect of an Active Fraction Extracted from Dragon's Blood (Dracaena Cochinchinensis)

作者：Gu Hui Juan; Lv Jing Ci; Yong Ke Lan^*; Chen Xu; Liu Pei Pei; Zhang Xia Bing

来源：Journal of Enzyme Inhibition and Medicinal Chemistry, 2009, 24(1): 136-139.

DOI：10.1080/14756360801936399

• dragon's blood
• extraction
• -glucosidase
• active fraction
• enzyme kinetics
• inhibition

The active fraction extracted from dragon's blood displayed an inhibitory effect on alpha-glucosidase activity with an IC50 of 0.152g/mL, which is nearly half of the crude material. Its inhibition on alpha-glucosidase was noncompetitive. In addition, when this fraction was orally administered to mice dosed with Acarbose (20mg/kg), the active fraction (100, 300, 500mg/kg) significantly suppressed increase of blood glucose levels after sucrose loading in a dose-dependent manner. These results suggest that this extract from dragon's blood exerts an anti-diabetic effect by suppressing intestinal carbohydrate absorption and thereby reducing the postprandial increase of blood glucose.

• 出版日期2009
• 单位上海大学