Abdominal adiposity is associated with fatty acid desaturase activity in boys: Implications for C-reactive protein and insulin resistance

作者：Saito Emiko; Okada Tomoo^*; Abe Yuriko; Odaka Minako; Kuromori Yuki; Iwata Fujihiko; Hara Mitsuhiko; Mugishima Hideo; Kitamura Yohei

来源：Prostaglandins, Leukotrienes and Essential Fatty Acids, 2013, 88(4): 307-311.

DOI：10.1016/j.plefa.2013.01.005

• Abdominal fat accumulation
• Delta-6 and 5 desaturases
• N-6 polyunsaturated fatty acid
• CRP
• Metabolic risk factors

Fatty acid composition, which is altered in patients with abdominal obesity, is influenced not only by dietary intake but also by the desaturating enzymes stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D). We investigated desaturase activities and their associations with metabolic risk factors, C-reactive protein levels (CRP) and insulin resistance in Japanese children. There were 237 school children in this study; 115 were boys. The fatty acid composition of plasma phospholipids was analyzed, and the following desaturase activities were estimated: SCD (16:1n-7/16:0 and 18:1n-9/18:0), D6D (20:3n-6/18:2n-6) and D5D (20:4n-6/20:3n-6). D6D and D5D activities, but not SCD activity, were significantly associated with triglyceride levels, high-density lipoprotein cholesterol levels and insulin resistance in both sexes, and with CRP levels in boys. In addition, increased abdominal adiposity was significantly associated with increased D6D activity, and decreased D5D activity and insulin resistance in both sexes, and with increased CRP levels in boys. The n-6 polyunsaturated fatty acid desaturation pathway may be associated with metabolic risk factors, insulin resistance and increased inflammation in children with abdominal obesity, especially in boys.

• 出版日期2013-4