CD-34 selected hematopoetic stem cell transplantation from HLA identical family members for fanconi anemia

作者：Balci Yasemin Isik; Akdemir Yasemin; Gumruk Fatma; Cetin Mualla; Arpaci Fikret; Uckan Duygu^*

来源：Pediatric Blood and Cancer, 2008, 50(5): 1065-1067.

DOI：10.1002/pbc.21424

• cd-34 selection
• fanconi anemia
• hematopoetic stem cell transplantation

Hematopoetic stem cell transplantation, even from an HLA 6/6 identical family member is associated with an increased frequency of complication in fanconi anemia (FA). The increased susceptibility for chromosomal breaks has been suggested as a contributory factor for increased risk of toxicity, graft versus host disease (GVHD) and increased incidence of post-transplant solid tumors. Therefore, non-irradiation based preparative regimens usually containing fludarabine and T-cell depletion of HLA genoidentical bone marrow cells have increasingly been used in patients with FA. Here, we report three children with FA who underwent CD-34 selected HSCT from HLA-identical family donors with reduced intensity fludarabine-based regimen.

• 出版日期2008-5
• 单位中国人民解放军军事医学科学院