A weighted-Holm procedure accounting for allele frequencies in genomewide association studies

作者：Dalmasso Cyril; Genin Emmanuelle; Tregouet David Alexandre^*

来源：Genetics, 2008, 180(1): 697-702.

DOI：10.1534/genetics.108.089839

In the context of genomewide association studies where hundreds Of thousand of polymorphisms are tested, stringent thresholds on the raw 7 association test P-values are generally used to limit false-positive results. Instead Of Using thresholds based on raw P-values as in Bonferroni and sequential Sidak (SidakSD) corrections, we propose here to Use a weighted-Holin procedure with weights depending on allele frequency Of the polymorphisms. This method IS shown to substantially improve the power to detect associations, in particular by favoring the detection of rare variants with high genetic effects over more frequent ones with lower effects.

• 出版日期2008-9