Adsorption of bombesin and its carboxyl terminal fragments onto the colloidal gold nanoparticles: SERS studies

作者：Tata Agnieszka; Szkudlarek Aleksandra; Kim Younkyoo; Proniewicz Edyta^*

来源：Vibrational Spectroscopy, 2016, 84: 1-6.

DOI：10.1016/j.vibspec.2016.02.006

• Bombesin (BN)
• Carboxyl terminal fragments of bombesin
• Surface-enhanced Raman scattering (SERS)
• Gold colloid

Surface-enhanced Raman scattering (SERS) is a Raman spectroscopy technique often used to study processes occurring at a solid/liquid interface. In this work, SERS was used to investigate the adsorption of bombesin (BN) and its C-terminal fragments adsorbed onto colloidal gold nanoparticles. Briefly, the SERS results demonstrated that (1) the elongation of the C-terminal peptide fragment causes movement of the Met (L-methionine) side-chain in the direction of the gold nanoparticles and the weakening of the interactions between the amide bond and gold; (2) the His (L-histidine) residue assists in the peptides interaction with the gold nanoparticles; and (3) Trp (L-tryptophan) dramatically changes the SERS spectral pattern on gold.

• 出版日期2016-5