A possible relationship between Toxoplasma gondii and schizophrenia: A seroprevalence study

作者：Dogruman Al Funda^*; Aslan Selcuk; Yalcin Safak; Kustimur Semra; Turk Songul

来源：International Journal of Psychiatry in Clinical Practice, 2009, 13(1): 82-87.

DOI：10.1080/13651500802624738

• Schizophrenia
• Toxoplasma gondii
• anti-Toxoplasma IgG
• anti-Toxoplasma IgM

Objective. Schizophrenia is a pervasive neuropsychiatric disease of uncertain etiology. We aimed to investigate a possible association between Toxoplasma gondii infection and schizophrenia in this study. Method. We selected individuals with schizophrenia (n=88) and tested them with commercially available enzyme-linked immunosorbent assay (ELISA) for anti-Toxoplasma IgG and IgM antibodies and compared these seropositivity rate to those of controls without psychiatric disease (n=88). Results. The rate of IgG antibody in the schizophrenia patients (47.7%) was higher than the control groups (20.4%) (P0.001). We did not find any anti-Toxoplasma IgM seropositivity in both schizophrenia patients and control group. In schizophrenic patients with and without anti-Toxoplasma IgG groups statistical analysis did not reveal any correlation between demographic variables and Toxoplasma infection. Conclusion. Our findings supported previous studies indicate that T.gondii may play a role in etiopathogenesis in some cases of schizophrenia.

• 出版日期2009