An 8-Week Low-Intensity Progressive Cycling Training Improves Motor Functions in Patients with Early-Stage Parkinson's Disease

作者：Chang Hsiu Chen; Lu Chin Song; Chiou Wei Da; Chen Chiung Chu; Weng Yi Hsin; Chang Ya Ju^*

来源：Journal of Clinical Neurology, 2018, 14(2): 225-233.

DOI：10.3988/jcn.2018.14.2.225

• Parkinson's disease
• exercise
• cycling
• gait

Background and Purpose The effects of high-intensity cycling as an adjuvant therapy for early-stage Parkinson's disease (PD) were highlighted recently. However, patients experience difficulties in maintaining these cycling training programs. The present study investigated the efficacy of cycling at a mild-to-moderate intensity in early-stage PD.& para;& para;Methods Thirteen PD patients were enrolled for 16 serial cycling sessions over a 2-month period. Motor function was assessed using the Unified Parkinson's Disease Rating Scale part III (UPDRS III) and Timed Up and Go (TUG) test as primary outcomes. The Montreal Cognitive Assessment (MoCA), modified Hoehn and Yahr Stage (mHYS), total UPDRS, Falls Efficacy Scale, New Freezing of Gait Questionnaire, Schwab and England Activities of Daily Living, 39-item Parkinson's Disease Questionnaire, Patient Global Impression of Change, and gait performance were assessed as secondary outcomes.& para;& para;Results The age and the age at onset were 59.67 +/- 7.24 and 53.23 +/- 10.26 years (mean +/- SD), respectively. The cycling cadence was 53.27 +/- 8.92 revolutions per minute. The UPDRS III score improved significantly after 8 training sessions (p=0.011) and 16 training sessions (T2) (p=0.001) in the off-state, and at T2 (p=0.004) in the on-state compared to pretraining (TO). The TUG duration was significantly shorter at T2 than at TO (p<0.05). The findings of MoCA, total UPDRS, double limb support time, and mHYS (in both the off- and on-states) also improved significantly at T2.& para;& para;Conclusions Our pioneer study has demonstrated that a low-intensity progressive cycling exercise can improve motor function in PD, especially akinesia. The beneficial effects were similar to those of high-intensity rehabilitation programs.

• 出版日期2018-4
• 单位长春大学