Novel Bu4N(+)Br(-) catalyzed one-pot multi-component synthesis of 2-amino nicotinonitriles in aqueous medium

作者：Kurumurthy C; Kumar R Naresh; Yakaiah T; Rao P Shanthan; Narsaiah B^*

来源：Research on Chemical Intermediates, 2015, 41(5): 3193-3199.

DOI：10.1007/s11164-013-1424-5

• Arylaldehydes
• Methylketones
• Malononitrile
• Nicotinonitrile
• Tetrabutyl ammonium bromide
• Ammonium acetate

An efficient single-pot strategy for 2-amino nicotinonitrile derivatives 5 has been developed by multi-component reaction of arylaldehydes 1, methylketones 2, malononitrile 3, and ammonium acetate 4 using tetrabutyl ammonium bromide as catalyst in aqueous medium.

• 出版日期2015-5