A letal case of gastro-intestinal basidiobolomycosis

作者：Cazorla Arnault^*; Grenouillet Frederic; Piton Gael; Faure Etienne; Delabrousse Eric; Mathieu Pierre; Viennet Gabriel; Kantelip Bernadette; Millon Laurence; Valmary Degano Severine

来源：Annales de Pathologie, 2014, 34(3): 228-232.

DOI：10.1016/j.annpat.2014.03.006

• Basidiobolosis
• Splendore-Hoeppli
• Pseudo-septated hyphae
• Gastro-intestinal form

We report here the case of a 55-year-old man from Mali, who presented with abdominal pain. Radiological exploration revealed an ileo-colonic mass surrounding the appendix. A biopsy was taken and on histology, transmural granulomatous inflammation of numerous eosinophils, lymphocytes, plasmocytes and giant cells was seen. Tuberculosis was suspected clinically and an antibiotic treatment was initiated. Two months later, the patient died of septic complications. Basidiobolus ranarum was identified by PCR. Pathogens were retrospectively highlighted on biopsies. These elements were between 10 and 15 mu m in diameter, occasionally pseudo-septated, and were surrounded by a thick eosinophilic cuff. The thick eosinophilic cuff was identified as the Splendore-Hoeppli phenomenon. Basidiobolomycosis is a well-known infection in the tropical areas. Basidiobolus sp., fungus of the order Entomophtorales are a known cause of chronic subcutaneous mycosis. Gastro-intestinal basidiobolomycosis is rare and presents considerable diagnostic difficulty. This infection needs to be diagnosed because surgical resection and prolonged antifungal treatment are curable in most cases.

• 出版日期2014-6