A model for the compressible, viscoelastic behavior of human amnion addressing tissue variability through a single parameter

作者：Mauri Arabella^*; Ehret Alexander E; De Focatiis Davide S A; Mazza Edoardo

来源：Biomechanics and Modeling in Mechanobiology, 2016, 15(4): 1005-1017.

DOI：10.1007/s10237-015-0739-0

• Biological membrane
• Compressible viscoelastic model
• Specimen variability
• Human amnion
• Creep
• Stress relaxation

A viscoelastic, compressible model is proposed to rationalize the recently reported response of human amnion in multiaxial relaxation and creep experiments. The theory includes two viscoelastic contributions responsible for the short- and long-term time-dependent response of the material. These two contributions can be related to physical processes: water flow through the tissue and dissipative characteristics of the collagen fibers, respectively. An accurate agreement of the model with the mean tension and kinematic response of amnion in uniaxial relaxation tests was achieved. By variation of a single linear factor that accounts for the variability among tissue samples, the model provides very sound predictions not only of the uniaxial relaxation but also of the uniaxial creep and strip-biaxial relaxation behavior of individual samples. This suggests that a wide range of viscoelastic behaviors due to patient-specific variations in tissue composition can be represented by the model without the need of recalibration and parameter identification.

• 出版日期2016-8