Differences in radiographic features of knee osteoarthritis in African-Americans and Caucasians: the Johnston County Osteoarthritis Project

作者：Braga L; Renner J B; Schwartz T A; Woodard J; Helmick C G; Hochberg M C; Jordan J M^*

来源：Osteoarthritis and Cartilage, 2009, 17(12): 1554-1561.

DOI：10.1016/j.joca.2009.07.011

• Osteoarthritis
• Knee
• Radiographic features
• Tibiofemoral joint
• Patellofemoral joint

Objective: To examine racial differences in tibiofemoral joint (TFJ) and patellofemoral joint (PFJ) radiographic osteoarthritis in African-American (AA) and Caucasian men and women.
Method Multiple logistic regression was used to evaluate cross-sectional associations between race and tibiofemoral osteoarthritis (TF-OA) and the presence, severity and location of individual radiographic features of tibiofemoral joint osteoarthritis [TFJ-OA] (osteophytes, joint space narrowing [JSN], sclerosis and cysts) and patellofemoral joint osteoarthritis (PFJ-OA) (osteophytes, JSN and sclerosis), using data from the Johnston County Osteoarthritis Project. Proportional odds ratios (POR) assessed severity of TF-OA, TFJ and PFJ osteophytes, and JSN, adjusting for confounders. Generalized estimating equations accounted for auto-correlation of knees.
Results: Among 3187 participants (32.5% AAs; 62% women; mean age 62 years), 6300 TFJ and 1957 PFJ were included. Compared to Caucasians, AA men were more likely to have TF-OA (adjusted odds ratio [aOR] = 1.36; 95% CI, 1.00-1.86); tri-compartmental TFJ and PFJ osteophytes (aOR = 3.06; 95%CI = 1.96-4.78), and TFJ and PFJ sclerosis. AA women were more likely than Caucasian to have medial TFJ and tri-compartmental osteophytes (aOR 2,13; 1.55-2.94), and lateral TFJ sclerosis. AAs had more severe TF-OA than Caucasians (adjusted cumulative odds ratio [aPOR] = 2.08; 95% CI, 1.19-3.64 for men; aPOR 1.56; 95% CI, 1.06-2.29 for women) and were more likely to have lateral TFJ JSN.
Conclusions: Compared to Caucasians, AAs were more likely to have more severe TF-OA; tri-compartmental disease; and lateral JSN. Further research to clarify the discrepancy between radiographic features in CA among races appears warranted.

• 出版日期2009-12