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摘要
Several derivatives of the novel benzo[b]pyrazolo[5,1:2,3]pyrimido[4,5-e][1,4]thiazine ring system have been synthesized through the one-pot cyclocondensation of 6-bromo-7-chloro-2-(ethylthio)-5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile (4) with o-aminothiophenol in the presence of Et3N in CH3CN. The true regio isomer (5) was also determined by X-ray crystallographic analysis. The N-alkylation of the synthesized compound (5) was also accomplished.
- 出版日期2016-7
