Activity-dependent energy budget for neocortical signaling: Effect of short-term synaptic plasticity on the energy expended by spiking and synaptic activity

作者：DiNuzzo Mauro^*; Giove Federico

来源：Journal of Neuroscience Research, 2012, 90(11): 2094-2102.

DOI：10.1002/jnr.23098

• neurometabolic coupling
• spiking activity
• synaptic activity
• short-term synaptic plasticity

The available estimate of the energy expended for signaling in rat neocortex is refined to examine the separate contribution of spiking and synaptic activity as a function of average neuronal firing rate. By taking into account a phenomenological model of short-term synaptic plasticity, we show that the transition from low to high cortical activity is accompanied by a substantial increase in relative energy consumed by action potentials vs. synaptic potentials. This consideration might be important for a deeper understanding of how information is represented in the cortex and which metabolic pathways are upregulated to sustain cortical activity.

• 出版日期2012-11