A comparative histopathological study of vocal fold polyps in smokers versus non-smokers

作者：Effat K G^*; Milad M

来源：Journal of Laryngology and Otology, 2015, 129(5): 484-488.

DOI：10.1017/S002221511500064X

• Vocal fold
• Polyps
• Smoking
• Histopathology

Background: A large proportion of patients with vocal fold polyps are cigarette smokers. However, prior to this report no comparative study of polyp histopathology in smokers versus non-smokers had been performed.
Methods: A prospective histopathological study of vocal fold polyps excised from 29 patients was undertaken. This comprised a comparative analysis of polyp histopathology in smokers versus non-smokers and a review of the pertinent literature.
Results: Vocal fold polyps were larger in smokers than in non-smokers. Histopathological features significantly associated with the polyps of smokers versus those of non-smokers were increased keratinisation, dysplasia, a basement membrane thinning and hyaline degeneration.
Conclusion: Cigarette smoke has an injurious effect on vocal fold polyp epithelium and leads to increased hyaline degeneration in polyps.

• 出版日期2015-5