New Glabretal Triterpenes from the Immature Fruits of Poncirus trifoliata and Their Selective Cytotoxicity

作者:Choi Ae Ran; Lee In Kyoung; Woo E Eum; Kwon Jin Won; Yun Bong Sik*; Park Hae Ryong
来源:Chemical & Pharmaceutical Bulletin, 2015, 63(12): 1065-1069.
DOI:10.1248/cpb.c15-00465

摘要

Two new glabretal triterpenes, pancastatins A (1) and B (2), were isolated from the immature fruits of Poncirus trifoliata. Their chemical structures were elucidated by spectroscopic analyses including one- and two-dimensional NMR and high-resolution electrospray ionization mass spectrometry. Compounds 1 and 2 exhibited selective cytotoxicity against PANC-1 pancreatic cancer cells under low-glucose stress conditions.

  • 出版日期2015-12