Anti- and prooxidant activity of triphenylantimony(V) catecholates derived from alkyl gallates

作者：Smolyaninov I V^*; Poddel'sky A I; Smolyaninova S A; Luzhnova S A; Berberova N T

来源：Russian Chemical Bulletin, 2015, 64(9): 2223-2231.

DOI：10.1007/s11172-015-1142-9

• catecholate complexes of triphenylantimony(V)
• redox-active ligands
• gallic acid esters
• antioxidant activity
• lipid peroxidation
• catalase activity

Antiradical and anti-and prooxidant activities of the newly obtained triphenylantimony(V) catecholate complexes derived from gallic acid esters of the general formulas (RO(O)C-Cat) SbPh3 (R = Me (1), C8H17 (2), C12H25 (3)) and (MeO(O) C-(OH center dot NEt3)Cat)SbPh3 (4) were studied. The comparative study involving gallic acid esters of the general formula RO(O)C-GallH(3) (R = Me (5), C8H17 (6), C12H25 (7)) was performed in order to evaluate the effect of organic ligands on the properties of the antimony(V) compounds. The values of EC50, the number of converted molecules of stable radical (nDPPH), as well as the relative content of oleic acid hydroperoxides confirm the antiradical and antioxidant activity of triphenyl-antimony(V) complexes in reactions with diphenylpicrylhydrazyl radicals and in the antioxidation of oleic acid. The influence of more active compounds 1 and 4 and ester 5 on lipid peroxidation of the rat liver homogenate of male Wistar line was determined. The membrane-protective properties were evaluated for induced hemolysis of erred blood cells as an example, and catalase activity of erythrocyte hemolysate was studied.

• 出版日期2015-9