Association between the c.910A>G genetic polymorphism in XRCC1 gene and susceptibility to lung cancer in a Chinese population

作者：Zhang Yong; Ni Huanjuan; Cheng Deyun^*

来源：Journal of Biological Research-Thessaloniki, 2013, 20: 270-275.

• lung cancer
• XRCC1 gene
• genetic polymorphisms
• molecular marker
• susceptibility
• risk factor

The human X-ray repair cross-complementing group 1 gene (XRCC1) is an important candidate gene influencing the susceptibility to lung cancer. This study aimed to investigate the association of c.910A>G genetic polymorphism in XRCC1 gene and lung cancer susceptibility. A total of 330 lung cancer cases and 333 cancer-free controls were enrolled. The genotypes of c.910A>G genetic polymorphisms were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Our data suggested that there were statistically significant differences in the allele and genotype frequencies between lung cancer patients and cancer-free controls. The GG genotype was statistically associated with the increased risk of lung cancer compared with the AA wild genotype [OR (odds ratio)=2.88, 95% CI: 1.62-5.13, p<0.001]. The allele G may contribute to lung cancer susceptibility (G vs A: OR=1.53, 95% CI: 1.20-1.94, p<0.001). These preliminary results indicate that the c.910A>G genetic polymorphism of XRCC1 gene is statistically associated with lung cancer susceptibility in Chinese population.

• 出版日期2013
• 单位四川大学