Association of MHC-I genotypes with disease progression in HIV/SIV infections

作者：Nomura Takushi; Matano Tetsuro^*

来源：Frontiers in Microbiology, 2012, 3: 234.

DOI：10.3389/fmicb.2012.00234

• CTL
• HIV
• HLA
• Mamu
• MHC-I
• MHC-I haplotype
• SIV

Virus-specific cytotoxic T lymphocytes (CTLs) are major effectors in acquired immune responses against viral infection. Virus-specific CTLs recognize specific viral peptides presented by major histocompatibility complex class-I (MHC-I) on the surface of virus-infected target cells via their T cell receptor (TCR) and eliminate target cells by both direct and indirect mechanisms. In human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections, host immune responses fail to contain the virus and allow persistent viral replication, leading to AIDS progression. CTL responses exert strong suppressive pressure on HIV/SIV replication and cumulative studies have indicated association of HLA/MHC-I genotypes with rapid or slow AIDS progression.

• 出版日期2012
• 单位河北医科大学