Association study of CYP3A5 genetic polymorphism with serum concentrations of carbamazepine in Chinese epilepsy patients

作者：Meng Hongmei; Ren Jinyan; Lv Yudan; Lin Weihong; Guo Yingjie^*

来源：Neurology Asia, 2011, 16(1): 39-45.

Objective: To investigate the association between the CYP3A5 genetic polymorphism and the serum concentrations of carbamazepine (CBZ), to provide guidance for individualized drug dosing. Methods: Eighty-four epilepsy patients taking CBZ were included in this study. Their clinical data were recorded and CBZ serum concentrations were measured. The CYP3A5 6986 genetic polymorphism was assessed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Patients were divided according to genotype into CYP3A5 expressor (CYP3A5*11 genotype and CYP3A5*13 genotypes) and non-expressor groups (CYP3A5*33). The two groups were compared for the total dose of CBZ, dose of CBZ/kg body weight, serum drug concentration, dose-corrected serum concentration, and standardized serum concentration. Results: The total dose of CBZ and the dose of CBZ/kg body weight was higher in the CYP3A5 expressor group than the non-expressor (P = 0.043 and P = 0.014, respectively). The dose-corrected and standardized serum concentrations were lower in the CYP3A5 expressor group than the non-expressor (P = 0.001 and P < 0.001, respectively). There was however, no significant difference in serum drug concentration between the two groups (P = 0.487).
Conclusions: There was a close relationship between CYP3A5 genetic polymorphism and the serum concentrations of carbamazepine.

• 出版日期2011-3
• 单位吉林大学