Association between SDF1-3 %26apos; A or CXCR4 gene polymorphisms with predisposition to and clinicopathological characteristics of prostate cancer with or without metastases

作者：Isman Ferruh K; Kucukgergin Canan; Dasdemir Selcuk; Cakmakoglu Bedia; Sanli Oner; Seckin Sule^*

来源：Molecular Biology Reports, 2012, 39(12): 11073-11079.

DOI：10.1007/s11033-012-2010-4

• SDF-1(CXCL12)
• CXCR4
• Single nucleotide polymorphism
• PCR-RFLP analysis
• Prostate cancer

In the present study, we aimed to investigate the association between SDF1-3%26apos;A and CXCR4 gene polymorphisms and the susceptibility and clinicopathological development of prostate cancer. SDF1-3%26apos;A and CXCR4 gene polymorphisms were assessed by polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP) in 149 healthy subjects and 152 patients with prostate cancer. There were no significant differences in the distributions of SDF-1 and CXCR4 genotypes between controls and prostate cancer patients. However, the patients with AA genotype of SDF1-3%26apos;A gene presented a higher risk for developing an advanced disease status as compared to patients with GG homozygotes (aOR = 2.02; 95 % CI = 1.05-3.90; P = 0.035). In addition, the distribution of AA genotype of SDF1-3%26apos;A gene was found significantly increased in the patients with bone metastasis in comparison to those without bone metastasis (aOR = 2.94; 95 % CI = 1.26-6.82; P = 0.012). On the other hand, CXCR4 gene polymorphism was not associated with the clinicopathological characteristics of prostate cancer. Our results suggest that SDF1-3%26apos;A and CXCR4 gene polymorphisms may not be risk factors for the susceptibility to prostate cancer. However, SDF1-3%26apos;A gene polymorphism may be associated with the progression and bone metastasis of prostate cancer in a Turkish men population.

• 出版日期2012-12