3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinoma

作者：Ren, Yu-Feng; Gao, Yuan-Hong; Cao, Xin-Ping^*; Ye, Wei-Jun; Teh, Bin S.

来源：Radiation Oncology, 2010, 5: 113.

DOI：10.1186/1748-717X-5-113

• EXTERNAL-BEAM RADIOTHERAPY
• DOSE-RATE BRACHYTHERAPY
• LOCAL-CONTROL
• INTRACAVITARY BRACHYTHERAPY
• ANDROGEN DEPRIVATION
• PROGNOSTIC-FACTORS
• HDR BRACHYTHERAPY
• RANDOMIZED TRIAL
• PROSTATE-CANCER
• CHEMOTHERAPY

Background: To compare the results of external beam radiotherapy in combination with 3D- computed tomography (CT) implanted interstitial high dose rate brachytherapy (ERT/3D-HDR-BT) versus conventional external beam radiotherapy (ERT) for the treatment of stage T2b nasopharyngeal carcinoma (NPC). @@@ Methods: Forty NPC patients diagnosed with stage T2b NPC were treated with ERT/3D-HDR-BT under local anesthesia. These patients received a mean dose of 60 Gy, followed by 12-20 Gy administered by 3D-HDR-BT. Another 101 patients diagnosed with non-metastatic T2b NPC received a mean dose of 68 Gy by ERT alone during the same period. @@@ Results: Patients treated with ERT/3D-HDR-BT versus ERT alone exhibited an improvement in their 5-y local failure-free survival rate (97.5% vs. 80.2%, P = 0.012) and disease-free survival rate (92.5% vs. 73.3%, P = 0.014). Using multivariate analysis, administration of 3D-HDR-BT was found to be favorable for local control (P = 0.046) and was statistically significant for disease-free survival (P = 0.021). The incidence rate of acute and chronic complications between the two groups was also compared. @@@ Conclusions: It is possible that the treatment modality enhances local control due to improved conformal dose distributions and the escalated radiation dose applied.

• 出版日期2010-11-23
• 单位中山大学