科研之友
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摘要
PURPOSE: To investigate the effectiveness and complications associated with the use of bevacizumab, an anti vascular endothelial growth factor agent, in the treatment of prethreshold retinopathy of prematurity (ROP). %26lt;br%26gt;DESIGN: A multicenter, retrospective case series. %26lt;br%26gt;METHODS: Data from patients who had received intravitreal bevacizumab (IVB) injections for the treatment of ROP were collected from 4 medical centers in Taiwan. The main outcome measures were the regression of ROP and the complications that were associated with the IVB injections. %26lt;br%26gt;RESULTS: In total, 162 eyes from 85 patients were included in the study. After receiving IVB injections, 143 eyes (88%) exhibited ROP regression. Fourteen eyes (9%) required additional laser treatment for ROP regression after the absence of a positive response to the IVB injections. Three eyes (2%) progressed to stage 4 ROP and required vitrectomies to reattach the retinas. Two eyes (1%) received 1 additional IVB injection to decrease persistent plus disease. All of the eyes (100%) had attached retinas after the various treatments that they received. The major ocular complications that were associated with IVB injections included vitreous or preretinal hemorrhage in 2 eyes (1%); cataract in 1 eye (1%); and exotropia in 1 eye (1%). No notable systemic complications related to the IVB injections were observed. %26lt;br%26gt;CONCLUSIONS: IVB injection seems to be an effective and well-tolerated method of treating prethreshold ROP. Laser therapy may still be required as a backup treatment for patients who do not respond to an IVB injection or for those in whom ROP worsens after an IVB injection. (Am J Ophthalmol 2013;155:150-158.
- 出版日期2013-1
- 单位长春大学
