Association between F508 deletion in CFTR and chronic pancreatitis risk

作者：Zhao, Dong; Xu, Yanzhen; Li, Jiatong; Fu, Shien; Xiao, Feifan; Song, Xiaowei; Xie, Zhibin; Jiang, Min; He, Yan; Liu, Chengwu; Wen, Qiongxian; Yang, Xiaoli^*

来源：Digestive and Liver Disease, 2017, 49(9): 967-972.

DOI：10.1016/j.dld.2017.06.013

• CFTR
• Chronic pancreatitis
• F508 deletion
• Idiopathic chronic pancreatitis
• Meta-analysis

Background: The cystic fibrosis transmembrane conductance regulator (CFTR) has been reported to influence individual susceptibility to chronic pancreatitis (CP), but the results of previous studies are controversial. @@@ Aims: We performed a study to demonstrate the relationship between CFTR and CP. @@@ Methods: We searched PubMed, Scopus, and Embase for studies of patients with CP. Seven studies from 1995 to 2016 were identified, and included 64,832 patients. Pooled prevalence and 95% confidence intervals (CIs) were calculated. @@@ Results: F508 deletion in CFTR was significantly positively associated with CP risk in the overall analysis (odds ratio [OR] = 3.20, 95% CI: 2.30-4.44, I-2 = 31.7%). In subgroup analysis stratified by ethnicity, F508 deletion was significantly associated with CP risk in Indian populations, using a fixed effects model (ORs = 5.45, 95% CI: 2.52-11.79, I-2 = 0.0%), and in non-Indian populations, using a random effects model (ORs = 3.59, 95% CI: 1.73-7.48, I-2 = 60.9%). At the same time, we found that Indians with F508 deletion had much higher CP prevalence than non-Indians. Interestingly, F508 deletion was also associated with CP and idiopathic CP risk in subgroup analysis stratified by aeitiology, using the fixed effects model. @@@ Conclusions: Based on current evidence, F508 deletion is a risk factor for CP, and Indians with F508 deletion have much higher CP morbidity.

• 出版日期2017-9
• 单位广西医科大学; 桂林医学院