Design and synthesis of 5-chloro-2-hydroxy-3-triazolylbenzoic acids as HIV integrase inhibitors

作者：Chen, Jie; Liu, Cheng-Fu; Yang, Cheng-Wen; Zeng, Cheng-Chu^*; Liu, Wei; Hu, Li-Ming

来源：Medicinal Chemistry Research, 2015, 24(7): 2950-2959.

DOI：10.1007/s00044-015-1325-9

• Click chemistry
• Diketo acids
• HIV IN inhibitors
• 2-Hydroxy-3-triazolylbenzoic acids
• Metal ion binding

A series of potential HIV-1 integrase inhibitors based on 5-chloro-2-hydroxy-3-triazolylbenzoic acid scaffold was designed and synthesized. Some of these compounds exhibit potent inhibitory activities at micromolar concentrations against HIV-1 integrase in the 3'-end processing and the strand transfer step.

• 出版日期2015-7
• 单位北京工业大学