Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens

作者：Schotanus Sietske M; Chergui Karima^*

来源：Neuropharmacology, 2008, 54(5): 837-844.

DOI：10.1016/j.neuropharm.2007.12.012

• long-term potentiation
• nucleus accumbens
• field excitatory postsynaptic potential
• dopamine receptors
• metabotropic glutamate receptors
• mouse

Long-term changes in the efficacy of glutamatergic synaptic transmission in the striatal complex are proposed to underlie motor learning and neuroadaptations leading to addiction. Dopamine and glutamate play key roles in the induction of long-term potentiation (LTP) and long-term depression (LTD) in the dorsal striatum, but their contribution to synaptic plasticity in the ventral striatum (nucleus accumbens, NAc) has been less extensively studied. We have examined the role of dopamine, glutamate and GABA in the induction of UP in mouse brain slices containing the NAc. High-frequency stimulation of glutamatergic inputs elicited LTP of field excitatory postsynaptic potentials/population spikes (fEPSP/PSs) in the core region of the NAc. GABA did not seem to participate in UP induction because UP was not altered in the presence of either a GABA(A)- (bicuculline) or a GABA(B)- (CGP 55845) receptor antagonist. However, the dopamine D1 receptor antagonist SCH 23390, but not the dopamine D2 receptor antagonist sulpiride, impaired UP. The dopamine reuptake blocker nomifensine also inhibited UP induction. We found that group I metabotropic glutamate receptors (mGluRs) contribute to UP induction because the mGluR1 antagonist LY 367385, or the mGluR5 antagonist MPEP, blocked UP induction. Furthermore, the glutamate reuptake blocker DL-TBOA also impaired UP. The present results demonstrate that dopamine and glutamate play critical roles in the mechanisms of induction of LTP in the NAc through the activation of dopamine D1 receptors and group I mGluRs. However, UP is negatively regulated when endogenous levels of dopamine or glutamate are elevated.

• 出版日期2008-4