Association of vitamin D receptor and estrogen receptor-a gene polymorphism with peak bone mass and bone size in Chinese women

作者：Qin, YJ^*; Zhang, ZL; Huang, QR; He, JW; Hu, YQ; Zhou, Q; Lu, JH; Li, M; Liu, YJ

来源：Acta Pharmacologica Sinica, 2004, 25(4): 462-468.

• bone density
• bone remodeling
• calcitriol receptors
• estrogen receptors
• restriction fragment length polymorphism
• gene frequency
• genotype
• female

AIM: To investigate if vitamin D receptor (VDR) gene Apa I polymorphism and estrogen receptor-alpha (ER-alpha) gene Pvu II, Xba I polymorphisms are related to bone mineral density (BMD), bone mineral content (BMC) and bone size in premenopausal Chinese women. METHODS: The VDR Apa I genotype and ER-alpha Pvu II, Xba I genotype were determined by PCR-restriction fragment length polymorphism (RFLP) in 493 unrelated healthy women aged 20-40 years of Han nationality in Shanghai city. BMD (g/cm(2)), BMC (g), and bone areal size (BAS, cm(2)) at lumbar spine 1-4 (L1-4) and proximal femur (femoral neck, trochanter and Ward's triangle) were measured by duel-energy X-ray absorptionmetry. RESULTS: All allele frequencies did not deviate from Hardy-Weinberg equilibrium. After phenotypes were adjusted for age, height, and weight, a significant association was found between VDR Apa I genotype and BMC variation at L1-4 and Ward's triangle (P<0.05), but not in BMD or BAS at lumbar spine and proximal femur. ER-alpha Pvu 11, Xba I genotype was not related to BMC, BMD, and BAS at all sites. CONCLUSION: The study suggested that Apa I polymorphism in VDR gene may influence on attainment and maintenance of peak bone mass in premenopausal Chinese women.

• 出版日期2004-4
• 单位上海交通大学