Determination of trace water contents of organic solvents by gas chromatography-mass spectrometry-selected ion monitoring

作者：Xu, Bai-Qiu; Rao, Chang-Quan; Cui, Shu-Fen; Wang, Jie; Wang, Jin-Lin; Liu, Li-Ping^*

来源：Journal of Chromatography A, 2018, 1570: 109-115.

DOI：10.1016/j.chroma.2018.07.068

• Organic solvent
• Trace water determination
• Gas chromatography-mass spectrometry (GC-MS)
• Selected ion monitoring (SIM)

This paper describes the development of a novel gas chromatography-mass spectrometry-selected ion monitoring (GC/MS-SIM) method for the determination of trace water contents of organic solvents, using the characteristic m/z 18, m/z 17, and m/z 16 ions of H2O as the qualitative ion and the m/z 18 ion as the quantifier ion. The accuracy and precision of this method were validated. An excellent linear correlation was obtained for trace water contents between 0 and 0.5217 wt%, with a correlation coefficient (R-2) of 0.9999, in addition to spike recoveries of 82.6-112,6%, and relative standard deviations (n = 6) of 0.4-7.2%. The limit of detection (S/N = 3) and limit of quantitation (S/N = 10) for the trace water contents of organic solvents were 0.0005% wt% and 0.0016% wt%, respectively.The analytical results confirmed that this method was useful for determining the trace water contents of organic solvents, because it has a low detection limit and wide linear range. It requires only small amounts of the samples and enables sample batch analysis. It is very environmentally friendly and saves reagents.

• 出版日期2018-10-5
• 单位深圳职业技术学院