Application of an in vivo swine model for the determination of arsenic bioavailability in contaminated vegetables

作者：Juhasz Albert L^*; Smith Euan; Weber John; Rees Matthew; Rofe Allan; Kuchel Tim; Sansom Lloyd; Naidu Ravi

来源：Chemosphere, 2008, 71(10): 1963-1969.

DOI：10.1016/j.chemosphere.2007.12.021

• arsenic
• bioavailability
• in vivo
• risk assessment
• vegetables

Considerable information is available in the literature regarding the uptake of arsenic (As) from contaminated soil and irrigation water by vegetables. However, few studies have investigated As speciation in these crops while a dearth of information is available on As bioavailability following their consumption. In this study, the concentration and speciation of As in chard, radish, lettuce and mung beans was determined following hydroponic growth of the vegetables using As-contaminated water. In addition, As bioavailability was assessed using an in vivo swine feeding assay. While As concentrations ranged from 3.0 to 84.2 mg As kg(-1) (dry weight), only inorganic As (arsenite and arsenate) was detected in the edible portions of the vegetables. When As bioavailability was assessed through monitoring blood plasma As concentrations following swine consumption of As-contaminated vegetables, between 50% and 100% of the administered As dose was absorbed and entered systemic circulation. Arsenic bioavailability decreased in the order mung beans > radish > lettuce = chard.

• 出版日期2008-5
• 单位河北医科大学