N-arylation of heterocycles catalyzed by activated-copper in pure water

作者：Yang Qichao; Wang Yufang; Lin Dong; Zhang Mingjie^*

来源：Tetrahedron Letters, 2013, 54(15): 1994-1997.

DOI：10.1016/j.tetlet.2013.02.004

• N-arylation
• Activated copper
• Heterocycle
• Aqueous medium
• Ullmann reaction

Activated-copper powder is an efficient catalyst for the N-arylation of heterocycles with aryl halides and can be reused several times. The reactions can proceed smoothly in water by using LiOH as base and give the corresponding products in good yields. The protocol shows good tolerance toward various functional groups.

• 出版日期2013-4-10
• 单位天津大学; 南阳师范学院