Acceleration of CuI-catalyzed coupling reaction of alkyl halides with aryl Grignard reagents using lithium chloride

作者：Nakata Kenya; Feng Chao; Tojo Toshifumi; Kobayashi Yuichi^*

来源：Tetrahedron Letters, 2014, 55(42): 5774-5777.

DOI：10.1016/j.tetlet.2014.08.089

• Coupling reaction
• Lithium chloride
• Acceleration
• Copper catalyst
• Grignard reagent

In the presence of LiCl, CuI-catalyzed coupling reaction of R(alkyl)-X with Ar(aryl)MgBr at rt was completed within 2 h. Effective leaving groups X in R-X were Br, I, OTs, but not Cl. Grignard reagents ArMgBr with both standard and bulky Ar such as 2-MeC6H4, 2-MeOC6H4, and 2,6-(Me)(2)C6H3 afforded the desired products in good yields. Ester and cyano groups in R-X were tolerated. Coupling reaction with R(alkyl)-MgBr proceeded as well.

• 出版日期2014-10-15