A Framework for Genetic Logic Synthesis

作者：Vaidyanathan Prashant^*; Der Bryan S; Bhatia Swapnil; Roehner Nicholas; Silva Ryan; Voigt Christopher A; Densmore Douglas

来源：Proceedings of the IEEE, 2015, 103(11): 2196-2207.

DOI：10.1109/JPROC.2015.2443832

• Boolean
• digital
• genetic
• logic
• synthesis
• synthetic biology
• transcription

Digital electronic circuits have inspired synthetic biologists to program living cells with synthetic decision-making circuits by creating multilevel genetic logic gates. In both genetic and electronic circuits, logic synthesis translates an abstract functional description into a representation that can be physically implemented. However, inherent differences in genetic logic devices present new synthesis challenges. Here we provide a starting point for a growing set of biodesign automation tools to tackle this challenge in a unified way. This framework will enable direct comparison of new approaches, results that are transferable and standardized, and research into independent areas of the problem formulation with a clear path toward future integration.

• 出版日期2015-11
• 单位MIT