Air pollution and airway resistance at age 8 years - the PIAMA birth cohort study

作者：Finke Isabelle; de Jongste Johan C; Smit Henriette A; Wijga Alet H; Koppelman Gerard H; Vonk Judith; Brunekreef Bert; Gehring Ulrike^*

来源：Environmental Health, 2018, 17(1): 61.

DOI：10.1186/s12940-018-0407-9

• Air pollution
• Children
• Interrupter resistance
• Particulate matter
• Nitrogen dioxide

Background: Air pollution has been found to adversely affect children's lung function. Forced expiratory volume in 1 s and forced vital capacity from spirometry have been studied most frequently, but measurements of airway resistance may provide additional information. We assessed associations of long-term air pollution exposure with airway resistance.
Methods: We measured airway resistance at age 8 with the interrupter resistance technique (R-int) in participants of the Dutch PIAMA birth cohort study. We linked R-int with estimated annual average air pollution concentrations [nitrogen oxides (NO2, NOx), PM2.5 absorbance ("soot"), and particulate matter < 2.5 mu m (PM2.5), < 10 mu m (PM10) and 2.5-10 mu m (PMcoarse)] at the birth address and current home address (n = 983). Associations between air pollution exposure and interrupter resistance (R-int) were assessed using multiple linear regression adjusting for potential confounders.
Results: We found that higher levels of NO2 at the current address were associated with higher R-int [adj. mean difference (95% confidence interval) per interquartile range increase in NO2: 0.018 (0.001, 0.035) kPa.s.L-1]. Similar trends were observed for the other pollutants, except, PM10. No association was found between R-int and exposure at the birth address.
Conclusions: Our results support the hypothesis that air pollution exposure is associated with a lower lung function in schoolchildren.

• 出版日期2018-7-17