Antiviral Activity of Solanum paniculatum Extract and Constituents

作者：Valadares Ydia M; Brandao Geraldo C; Kroon Erna G; Souza Filho Jose D; Oliveira Alaide B; Braga Fernao C^*

来源：Zeitschrift fur Naturforschung Section C-A Journal of Biosciences, 2009, 64(11-12): 813-818.

DOI：10.1515/znc-2009-11-1210

• Solanum paniculatum
• Delta(25(27))-Tigogenin-3-O-beta-D-glucopyranoside
• Antiviral Activity

Solanum species are traditionally employed as antiherpes and anticancer agents ill different countries. S. paniculatum has widespread ethnomedical uses in Brazil, including the treatment of viral infections. This paper reports on the isolation of neotigogenin (1) and the new compound Delta(25(27))-tigogenin-3-O-beta-D-glucopyranoside (2), obtained as a mixture of R and S diastereoisomers at C22 from an ethanol extract of S. paniculatum? leaves, along with the determination of their cytotoxicity against Vero cells and antiviral effect against human herpes virus type I (HHV-1), murine encephalomyocarditis Virus (EMCv), and vaccinia virus strain Western Reserve (VACV-WR). The extract of S paniculatum inhibited HHV-1 replication [EC(50) = (298.0 +/- 11.2) mu g/ml] and showed no effect oil EMCv and VACV-WR. On its turn. I was inactive against the assayed strains but presented high cytotoxicity [CC(50) = (2.03 +/- 0.03) mu g/ml], whereas 2 exhibited significant antiherpes [EC(50) = (170.8 +/- 1.7) mu g/ml] and antivaccinia virus effects [EC(50) = (177.0 +/- 3.3) mu g/ml], with low cytotoxicity (CC(50) > 400 mu g/ml). The results corroborate Solanum paniculatum as a source of cytotoxic and antiviral compounds.

• 出版日期2009-12