Determination of atropisomeric configurations of macrocyclic bisbibenzyls by HPLC-CD/UV and quantum chemical calculations

作者：Wang Li Ning; Xie Chun Feng; Zhu Xiao Song; Fan Pei Hong; Lou Hong Xiang^*

来源：Journal of Asian Natural Products Research, 2011, 13(4): 312-318.

DOI：10.1080/10286020.2011.555333

• Reboulia hemisphaerica
• atropisomer
• bisbibenzyls
• online HPLC-CD
• quantum chemical CD calculations

Isoriccardin C (1) and riccardin D (2), isolated from the liverwort Reboulia hemisphaerica, were first characterized to be a mixture of two enantiomeric atropisomers by online chiral high-performance liquid chromatography-circular dichroism (HPLC-CD) analysis. Exemplarily for bisbibenzyls of the diarylether-biphenyl type, the absolute atropisomeric configurations of compunds 1 and 2 were determined by the analysis of their CD data coupled with quantum chemical CD calculations.

• 出版日期2011
• 单位山东大学