A DNA-Based Candidate HIV Vaccine Delivered via In Vivo Electroporation Induces CD4 Responses toward the alpha 4 beta 7-Binding V2 Loop of HIV gp120 in Healthy Volunteers

作者：Kopycinski Jakub^*; Cheeseman Hannah; Ashraf Ambreen; Gill Dilbinder; Hayes Peter; Hannaman Drew; Gilmour Jill; Cox Josephine H; Vasan Sandhya

来源：Clinical and Vaccine Immunology, 2012, 19(9): 1557-1559.

DOI：10.1128/CVI.00327-12

Administration of a clade C/B' candidate HIV-1 DNA vaccine, ADVAX, by in vivo electroporation (EP) was safe and more immunogenic than intramuscular administration without EP. The breadth and specificity of T-cell responses to full-length Env were mapped. Responses to multiple Env regions were induced, with most focusing on V3/C4 and V2 regions, including the alpha 4 beta 7 integrin-binding domain. The breadth of responses induced by this DNA vaccine regimen was comparable to that of viral-vectored vaccine regimens.

• 出版日期2012-9