Novel styrylpyridines as probes for SPECT imaging of amyloid plaques

作者：Qu Wenchao; Kung Mei Ping; Hou Catherine; Benedum Tyler E; Kung Hank F^*

来源：Journal of Medicinal Chemistry, 2007, 50(9): 2157-2165.

DOI：10.1021/jm070025+

We report a series of radioiodinated styrylpyridines as single photon emission computed tomography probes for imaging A beta plaques in the brain of patients with Alzheimer's disease (AD). In vitro binding showed that all of the styrylpyridines displayed very good binding affinities in postmortem AD brain homogenates (K-i = 3.6 to 15.5 nM). No-carrier-added samples of 13a, 13b, 16a, 16b, and 16e (radioiodinated with I-125) were successfully prepared. The in vivo biodistribution in normal mice, at 2 min after injection, showed excellent initial brain penetrations (4.03, 6.22, 5.43, and 8.04% dose/g for [I-125]13a, 13b, 16a, and 16b, respectively). Furthermore, in vitro autoradiography of AD brain sections showed that the high binding signal was specifically due to the presence of A beta plaques. Taken together, these results strongly suggest that these styrylpyridines are useful for imaging A beta plaques in the living human brain.

• 出版日期2007-5-3