Application of chiral (Thio)urea derivatives in asymmetric organocatalysis

作者：Wu Qiu Hua^*; Gao Yong Jun; Li Zhi; Wang Jun Min; Wang Chun; Ma Jing Jun; Song Shuang Ju

来源：Chinese Journal of Organic Chemistry, 2007, 27(12): 1491-1501.

• asymmetric organocatalysis
• enantioselectivity
• chiral urea and thiourea

Chiral (thio)urea derivatives are very effective organocatalysts for the nuclephilic addition reactions of imines, aldehydes, electron-deficient olefins, etc. They have been successfully applied in varieties of enantioselective organic reactions, such as asymmetric Strecker, Michael addition, Mannich, Baylis-Hillman, Acyl-Pictet-Spengler and Henry reactions as well as the dynamic kinetic resolution. Chiral (thio)urea derivatives are rapidly emerging as versatile, high catalytic active, low catalyst loading, excellent enantioselective, high functional group tolerant, ease of prepared/modified organocatalyst for the promotion of a wide range of synthetically useful asymmetric processes. The application of chiral (thio)urea derivatives in asymmetric organocatalysis is reviewed in this paper.

• 出版日期2007-12
• 单位河北农业大学