A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines

作者：Kalinina Svetlana A; Kalinin Dmitrii V; Dolzhenko Anton V^*

来源：Tetrahedron Letters, 2013, 54(40): 5537-5540.

DOI：10.1016/j.tetlet.2013.07.158

• Multicomponent reaction
• Microwave-assisted synthesis
• Triazoles
• Triazines
• Purine isosters

A new, efficient, catalyst-free, one-pot, three-component method for the synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines using 3,5-diamino-1,2,4-triazoles, cyanamide, and triethyl orthoformate is developed. The reaction proceeds smoothly under microwave-assisted heating. Advantages of the method include using easily available reagents, short reaction times, and operational simplicity.

• 出版日期2013-10-2